Lack of Caffeine Stimulation of Gastrin Release in Man 1

Abstract

Summary and conclusions

Caffeine ben-zoate given intravenously to four subjects (two with duodenal ulcer and two normals) in dose-responsive tests at 80 and 320 mg/hr stimulated gastric H⁺ and pepsin secretion two- and threefold, respectively, but did not change serum gastrin levels. In five patients with duodenal ulcer and six normals, 250 mg of caffeine benzoate intragastrically, but not an equivalent volume of water, raised serum gastrin concentrations by 16 to 22 pg/ ml (P < 0.05). There was no difference in caffeine-stimulated gastrin release between the duodenal ulcer group and normals.