Elevated Expression of T-Antigen in Skin Fibroblasts from Individuals with Cytogenetic Anomalies Infected in Vitro with Simian or Human Papovaviruses 1

Abstract

Summary

Human skin fibroblasts were infected with human papovavirus (BK type) or simian papovavirus 40 (SV40) at multiplicities of infection which induced similar frequencies of T-antigen-containing cells at 72 hr after infection. Both viruses exhibited a higher rate of T-antigen expression in cells from genetically abnormal individuals with Fanconi anemia, Turner's syndrome, or Klinefelter's syndrome than in cells from normal individuals.

The authors wish to express their gratitude to Mark Gunnell, Thomas Archer, Elizabeth Alexander, and Carole Yee for their excellent technical assistance, and Celeste Martin for her patient secretarial assistance.