H 1 - and H 2 -Histamine Receptor Antagonists and Protection against Traumatic Shock 1

Abstract

Summary

Pretreatment of mice with four different Hi-receptor antagonists (i.e., di-phenhydramine, promethazine, pyrilamine, and pyribenzamine) exerted significant protection against Noble-Collip drum trauma (NCDT). Blockage of H₂-receptors, however, was associated with an exacerbation of mortality after NCDT. These results suggest that certain actions of histamine on H₂-re-ceptors could be beneficial in NCDT in mice, while actions on Hx-receptors may be detrimental.