Abstract
Summary
To obtain evidence about the controversial role of the gastric mucosal barrier to back-diffusion of hydrogen ions in the pathogenesis of gastric ulcerations during restraint-stress, rats were subjected to restraint stress for 24 hr and acid instillations performed in their pylorus ligated stomachs with a technique adapted from previously described methods for acid instillation in canine dog pouches. Since the rat's pylorus ligated stomach does not tolerate solutions with high hydrogen ion (H+) concentrations, test solutions containing H+ of 55 meq/liter were used. Hydrogen ion secretion did not decrease in these stressed rats, but there was a marked increase in H+ back-diffusion across the gastric mucosa which was well correlated with the gross visual damage. Abnormal gastric mucosal permeability to hydrogen ion may play a pathogenic role in restraint-stress induced ulceration.
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