Acetate Influence upon the Transport Kinetics of p-Aminohippurate at 37°C in Rabbit Kidney Slices

Abstract

Summary

The present investigation involving p-aminohippurate uptake by rabbit kidney slices has shown (i) confirmative evidence that p-aminohippurate uptake is stimulated by the presence of acetate at both 25 and 37°; (ii) oxygen consumption being stimulated by acetate at 25 but not at 37°; (iii) the K _m for p-aminohippurate uptake at 37° is not affected by the presence of acetate in the medium; (iv) the V _max for p-amino-hippurate uptake at 37° is directly related to the presence of acetate in the medium; and (v) acetate stimulates ATP utilization at 37° but does not alter energy charge potential.