Abstract
Summary
Previous work in this laboratory has shown that the adsorption of IgG antibody-sensitized erythrocytes by tumor and normal spleen tissues can be inhibited by immune complexes and heat-aggregated IgG. The present study showed that sera from mice immunized with syngenic tumor cells inhibited adsorption of sensitized erythrocytes by tumor and spleen tissues. These sera inhibited also hemadsorption by allogenic tumor tissue and, significantly, by syngenic as well as allogenic spleen tissue.
These results support the contention that sera from tumor-bearing animals contain immune complexes which block the Fc receptors of tumor and spleen cells indiscriminately.
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