Lysis of Cytomegalovirus-lnfected Human Fibroblasts and Transformed Human Cells by Peripheral Blood Lymphoid Cells from Normal Human Donors 1

Abstract

Summary

Peripheral blood leukocytes from 14 healthy, nonimmune, human donors were capable of destroying CMV-in-fected human fibroblasts, but non unin-fected fibroblasts. Antibody did not appear to mediate the response. Cytotoxicity in a similar range was noted when three transformed human cell lines were used as target cells. Unlike adult leukocytes, leukocytes separated from three samples of cord blood were ineffective in destroying CMV-in-fected target cells.

We thank Dr. Roberto Kretschmer for providing cord blood and Ricki Peitchel for technical assistance.