Abstract
Summary
Cell proliferation is inhibited in rat glioma (strain C6) monolayer cultures treated with cortisol (>1. μM) or dexameth-asone (>0.001 μM). Transient growth-inhibitory responses occur at 3 μM cortisol and 0.01-0.03 μM dexamethasone. At higher glucocorticoid concentrations, non-transient inhibitory responses persist for 5 days. Dose-response curves show that dexamethasone is 250 to 300 times more potent than cortisol in suppressing C6 growth.
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