Abstract
Summary
Three nitrogen-containing can-nabinoids caused a dose-dependent fall of intraocular pressure when administered either topically or orally to rabbits. Concentrations of 0.001 to 1% applied topically and 0.3 mg/kg orally were effective. Topical concentrations of 0.5% caused a substantial decrease of intraocular pressure in rhesus monkeys. These compounds may prove therapeutically useful in the treatment of elevated intraocular pressure.
This work was supported in part by PHS Research Grants EY 01413, EY 01590 and DA 01213. We thank Dr. Harry Pars of SISA, Inc., Cambridge, Mass., for the generous supplies of the benzopyranopyridines, Ms. D. Hancock and Mrs. I. Prior for secretarial assistance, Ms. K. Bowman and Ms. D. Johnson for technical assistance, and Drs. M. Kling, R. Shimp and Mr. R. Morrison for their help with the monkey experiments.
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