Abstract
Summary
Rats fasted for periods of 24, 48, or 72 hr showed no changes in plasma glucagon concentration despite lowered blood glucose concentration. Islets isolated from both fed and fasted animals elicited biphasic glucagon and insulin secretion when stimulated with arginine and glucose, respectively. There were no differences in glucagon secretion rates between islets prepared from fed and fasted animals. Significant reductions in both the first and second phases of insulin secretion were observed in islets prepared from fasting animals.
The authors wish to thank Ms. Carol Grimme and Ms. D. Barr for typing the manuscript, and Dr. A. Pagliara for anti-glucagon serum. This work was made possible by Public Health Service Grant AM-165 34.
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