Solubilization of Initial Attachment Site Activity for Avian Tumor Viruses with Lithium Diiodosalicylate 1

Abstract

Summary

Extraction of CEF plasma membranes with LIS solubilizes membrane components which interact directly with ATV in vitro, antagonizing ATV binding to CEF plasma membranes and reducing the transforming capacity of these viruses. This activity is specific to CEF; approximately 200 human erythrocytes must be extracted with LIS to produce the activity equivalent to that extractable from a single CEF.