Abstract
Summary
Extracts of HSV-2-trans-formed hamster cells inhibit plaque formation of HSV-1 and HSV-2 in normal hamster cells. Extracts also inhibit replication of HSV. The inhibitor is a soluble component of the cells, and probably does not act directly on extracellular virus. The inhibitor is not a classicial interferon since the inhibition is temperature-sensitive and the replication of VSV is not impaired.
Dr. Ronald Duff supplied helpful suggestions for this study. This investigation was supported by Contract NO1 CP 53516 within the Virus Cancer Program of the National Cancer Institute, NIH, PHS.
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