Abstract
Summary
Chronic administration of hal-ofenate at two dose levels (30 and 60 mg/ kg) to male retired breeder rats caused a significant lowering of serum cholesterol levels. Halofenate treatment also produced hepatomegaly in rats, and this increase in liver weight was due, at least in part, to an increase in the quantity of triglyceride. Considerable mortality (4/11) was associated with the higher dose level. The influence of pretreatment with halofenate on several parameters of hepatic microsomal drug metabolism was investigated. In vitro ethylmor-phine iV-demethylation was increased and the concentrations of cytochrome P-450 and cytochrome b5 were elevated. The specific activity of NADPH-cytochrome c reductase was also increased.
The authors thank Merck, Sharp & Dohme Laboratories for a supply of halofenate. We wish to also thank Mrs. Naomi Ross for typing the manuscript.
Get full access to this article
View all access options for this article.