Abstract
Summary
When angiotensin II is injected into the cerebral ventricles of the rat, drinking and a short latency pressor response are produced. We have found that the pressor response has two components. The first component is always associated with angiotensin injections. The second component, however, is associated with drinking behavior. If water is not available, the second pressor component is absent. We have investigated this drinking-associated pressor response and find that it is not only seen when angiotensin is the stimulus, but also in normal or carbachol-induced drinking. The effect is not due to head position during drinking or hypoxia but it is mediated by the sympathetic nervous system since it is abolished by alpha-adrenergic blockage.
We are grateful for the technical assistance of Judy Phipps and to Dr. J. Farber for advice. This work was supported by Program Project Grant No. HI07007 to W. E. H., NSF Grant No. BNS75-16364 to M. I. P. and Grant No. MRIS 7737.03 from the Veterans Administration to Phillip G. Schmid, M.D.
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