Abstract
Summary
Oral administration of fenflur-amine for 8 weeks reduced food intake and body weight in ob/ob, GTG, and nonobese mice. The hyperglycemia and hyperinsuline-mia present in the ob/ob mice were significantly reduced by this drug. Plasma glucose, but not insulin, was significantly reduced in GTG mice; neither was significantly reduced in nonobese mice. Fenfluramine reduced plasma triglycerides, but had no effect on liver glycogen concentration and did not reduce the percentage of body fat.
Partial support was provided by Grants No. AM-02911 and No. AM-00106 from NIH, USPHS, and the Fund for Research and Teaching, Department of Nutrition, Harvard School of Public Health. The fenfluramine · HC1 was a gift of Dr. Oscar Klioze. We wish to thank Teresa Pasquine for performing the insulin assays.
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