Abstract
Summary
NaCl-deprived rats given Nal to drink failed to suppress PRA compared to rats drinking equimolar amounts of NaCl, despite a more positive Na balance in the former group. Volume contraction and potassium deficiency do not appear to explain this observation. If chloride is a principal ion to signal the macula densa to release renin, our data suggest that iodide cannot substitute in such a role.
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