Abstract
Summary
The adipocyte size frequency distributions were determined during the preobese and obese phases of development in ob/ob and non-ob/ob mice. Only the small- and moderate-sized cells were evaluated. A procedure was presented that transformed composite data from the population distributions of individual samples into a form suitable for comparisons by chi-square. Among the obese animals, the frequency of small cells continued to increase during development, which resulted in a bi-modal distribution after 10 weeks of age. During the preobese phase of development at Week 3, the adipocyte size frequency distribution of the ob/ob mice was significantly different from that of non-ob/ob animals. Discriminant analysis suggested that adipocyte size frequency distributions may be used to identify ob/ob animals during the preobese phase of development.
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