Abstract
Summary
FSH treatment of hypophysec-tomized immature rats increased testicular weight, increased the number of LH receptors per testis, and increased the in vitro testicular testosterone production in response to LH. The increase observed in all three parameters was related to the duration of FSH treatment. The testicular response to LH was enhanced to a greater extent than the number of LH receptors. The specificity of the FSH effect was indicated by the observation that administration of LH had no effect on testicular weight or number of LH receptors. LH administration did not increase the in vitro testicular response to LH, but appeared to prevent the decrease in this response observed in saline-injected controls.
We thank Carol Craig for expert technical assistance. We also thank Dr. A. F. Parlow for the rat LH, NIAMDD-Rat LH-I-3, and NIAMDD for supplying the NIH-FSH-S11 and NIH-LH-S19. This study was supported by NIH Grant No. HD-08358.
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