Abstract
Summary
All of 20 children sampled who had received Enders' original measles vaccine, together with human immune globulin, retained measles antibody for 15 years with essentially no decline in antibody titer. All but one of 24 children who received Enders' original measles vaccine and all of 33 children who received more attenuated measles virus vaccine (Moraten line, Atte-nuvax) retained their antibody for 8 years, the longest time period tested. These data support the concept that the problems with efficacy of measles virus vaccine are more related to handling and administration of the vaccine itself than with the attributes of the vaccine.
The authors are indebted to Elizabeth D. Posner for statistical computations and to Robert R. Roehm, Susan A. Brown, Monica E. Hoover, and Helene M. Eliff for technical services. Karen Campbell provided valuable nursing assistance.
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