Abstract
Summary
The addition of promethazine hydrochloride to a suspension of rabbit alveolar macrophages in vitro results in an inhibition of cellular glucose oxidation under both resting and phagocytizing conditions as well as in an inhibition of phagocytosis of radiolabeled bacteria. The in vivo injection of the compound into rabbits partially suppresses the BCG-induced activation of the alveolar macrophages. These results suggest that the mechanism of action of promethazine hydrochloride in ameliorating the effects of erythroblastosis might lie, at least in part, in its ability to suppress the fetal macrophages which are responsible for red cell lysis.
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