Abstract
Summary
Evidence for infection of male and female guinea pigs by the chlamydial agent of guinea pig inclusion conjunctivitis (Gp-ic) following intrarectal inoculation was documented by recovery of the agent from rectal swabs up to Day 23 and from segments of intestinal tract to Day 17. Anti-body response to Gp-ic was demonstrated in the serum by Day 21 although titers were low as detected by indirect immunofluores-cence. In a few instances scrapings of intestinal tissue were found to contain cells with Gp-ic inclusions when stained with Giemsa. Gp-ic inclusions were also observed in ocular smears from males and females (8 positive/35 tested) as well as vaginal smears (2 positive/16 tested). These studies augment the value of this animal model system for the study of genital infections caused by Chlamydia.
This paper is devoted to our friend Doctor Felix Milgrom of the State University of New York at Buffalo on the occasion of the thirtieth anniversary of his research activities.
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