Somatostatin Inhibition of Glucagon-Stimulated Adenosine 3′-5′-Monophosphate Accumulation in Isolated Hepatocytes 1

Abstract

Summary

The cyclic form of somatotropin release inhibitor factor over a concentration range from 0.50 to 8.0 μg/ml was found to inhibit glucagon-stimulated cyclic AMP accumulation in isolated rat hepato-cytes.

The authors are grateful to Nancy Bridgforth, Ann Miller, Sue Wills, and Lucinda Carr for skilled technical assistance and to Deborah Barr and Carol Grimme for typing of the manuscript. The authors are also very grateful to Dr. R. Deghenghi of Ayerst Laboratories, Montreal, Quebec, Canada, for the supply of cyclic form somatostatin, Lot No. Ay-24,910.