Platelet Function Studies in Dogs with Cyclic Hematopoiesis 1

Abstract

Summary

Platelet adhesiveness, platelet clot retraction and fibrinogen determinations were made on dogs with cyclic hemato-poiesis (CH), dogs cured of CH disease via bone marrow transplantation, and normal dogs. Platelet adhesiveness and clot retraction values in CH dogs were below normal values throughout the cycle and were not influenced by neutropenic episodes. However, these platelet functions were normal in CH dogs transplanted with normal marrow. Fibrinogen values of CH dogs did fluctuate with the neutrophil cycle, but were continually elevated when compared to either normal dogs or CH dogs transplanted with normal marrow. By use of platelets and plasma from normal, CH, and transplant-CH dogs, it was shown that plasma from either normal dogs or CH dogs transplanted with normal marrow corrected the CH dogs'platelet clot retraction defect. These studies indicate that a plasma factor is involved in the decreased platelet function of CH dogs; furthermore, the plasma factor may be fibrinogen.

Sincere appreciation is expressed to Janet Jolly for fibrinogen determinations, to Cheryl Skeen and Beth Penn for stenographic services, and to Pat Wayne for art work.