Abstract
Summary
The effect of various experimental maneuvers in altering PRA of infant rats was studied. In 2-week-old animals, no suppression of PRA is found after saline loading or β-blockade. Infants nursed by mothers receiving 1% saline for drinking water show no changes in PRA from control levels. Intramuscular administration of ADH (0.2 U) in 2-week-old animals suppressed PRA, while P-113 resulted in a marked increase in PRA. These latter data suggest that some stimulus is causing inappropriate secretion of renin, and, in addition, there was some failure of feedback suppression by ADH.
This work was supported by a grant from the U.S./ Israel Binational Science Foundation, No. 474.
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