Abstract
Summary
Rats were injected subcutane-ously with synthetic secretin (100 units/kg) every 8 hr for 14 days. We examined the effect of secretin on the weight of the stomach and its component parts, on the biochemical characteristics of the oxyntic glandular mucosa, and on the levels of endogenous gastrin. Each of these measurements is capable of detecting changes in the growth of the stomach. Nevertheless, we found no evidence that secretin inhibits gastric growth. It is, therefore, concluded that secretin itself does not have an antitrophic effect on the rat stomach and that the previously reported antitrophic effect of secretin on this tissue was due to the inhibition of pentagastrin.
The authors wish to thank P. D. Guthrie for his technical assistance and M. I. Grossman for his advice during the course of this study. Secretin was a gift from Schwarz/Mann Inc.; Calcitonin diluent B was a gift from Armour Pharmaceutical Co. This work was supported in part by Grant AMI6505 and Research Career Development Award (to Dr. Johnson) AM 28972 from the National Institutes of Health.
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