Abstract
Summary
Proestrous serum LH and FSH levels and ovulation were significantly reduced when either γ-butyrolactone (GBL), which is hydrolyzed in vivo to the naturally occurring CNS depressant γ-hydroxybutyr-ate (GBH), or pimozide, a dopaminergic receptor blocker, was administered to 4-day cyclic rats just prior to the proestrous critical period. These data suggest that GBL and pimozide inhibit ovulation by decreasing the proestrous serum LH and FSH surges through effects on a central dopaminergic pathway.
The authors would like to express their appreciation to J. Bell, J. Tracy, G. Cole, and K. Koch for excellent technical assistance.
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