Abstract
Summary
The kinetics of erythroid proliferation have been studied in the newborn rat of different ages by the method of 3H-Tdr-labeled mitoses. The experimental results have been analyzed by the method of Steel and Hanes (7).
A generation time of 10 hr has been obtained in the adult rats for the proerythro-blasts and basophilic erythroblasts, while in the newborn rat the generation time for the same cells was found to be of the order of 7.5 hr. It has been shown that these reductions are mainly due to decrease in the duration of G1 and G2 phases.
The possibility is suggested that the shorter cell-cycle of the erythroid cells could, at least in part, account for the erythroid hyperplasia observed in the rat during the first 2 weeks of life.
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