Induction of Erythroid Colony Forming Cells (CFU-E) in Murine Spleen by Endotoxin 1

Abstract

Summary

Injection of endotoxin induced in the spleens of normal and of polycy-themic mice a dose-related increase in CFU-E. In the intact normal mice these precursors developed into erythroblasts and resulted in increases in ⁵⁹Fe incorporation into heme. In mice whose endogenous Ep was suppressed by polycythemia no differentiation of the precursors took place. The time course of the CFU-E increase after endotoxin suggests proliferation of precursors as the most plausible mechanism.