Abstract
Summary
Effects of estrogen administration were compared in young (2-5 months) and aged (2.0-2.5 years), ovariectomized NIH Swiss mice. Two murine leukemia virus proteins, p30 and RNA-directed DNA polymerase, were markedly elevated by estrogen in the uteri of young, ovariectomized mice, but behaved differently in aged animals. The polymerase was low or absent in the uteri of aged mice and showed no increase in response to estrogen. In contrast, p30 responded to estrogen in the aged animals much the same as in the younger mice. This implies that the production of these viral proteins is under separate control mechanisms.
The authors gratefully acknowledge the excellent technical assistance of Glenn He-gamyer, Carl Reed, Cindy Lin, and Leon Culler. We thank Ruby Howard for histo-logical preparations, and Dr. Richard Olsen for histological evaluation of our tissue specimens.
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