Abstract
Summary
After nephrectomy, plasma or serum acquires the property of stimulating angiotensinogen (A) synthesis in liver slices from normal rats. The possibility that this angiotensinogen stimulating activity (ASA) may be an artifact arising from exposure of the tissue to the high levels of A in the test material has been examined. It has now been found that ASA and A can be separated by electrophoresis on starch powder and gradient elution from DEAE cellulose. The identification of ASA as a distinct component of the renal-pressor system raises new prospects for investigation of control mechanisms within the system.
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