Abstract
Summary
A new broad-spectrum antimicrobial, 2-amino-5-(l-methyl-5-nitro-2-imi-dazolyl)-1,3,4-thiadiazole, reported inactive against Mycobacterium tuberculosis, inhibited multiplication of M. leprae in the mouse foot pad when administered orally to the mice. The dose-response curve was very steep: 0.2 g% of the drug exhibited considerable activity, whereas 0.05 g% was only modestly active in one experiment and inactive in another. This drug appears to be one of the few that is bactericidal for M. leprae.
This work was partially supported by the U. S. Leprosy Panel of the U. S.-Japan Cooperative Medical Science Program administered by the Geographic Medicine Branch, National Institute of Allergy and Infectious Diseases (Grant R 22 AI 07801). Supplies of 2-amino-5-(l-methyl-5-nitro-2-imidazolyl)-1,3,4-thiadi-azole were generously furnished by Lederle Laboratories, Pearl River, New York.
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