Abstract
Summary
Calcium directly stimulates renin release from rat kidney slices previously treated with calcium-free medium. The stimulant effect of calcium (0.5 or 6.0 mM) is not seen without the period of calcium depletion. The stimulant effect of calcium is still present in sodium-free medium but is reduced when the incubation is performed at 20° instead of 37°. The results suggest that the underlying mechanism of renin release may be comparable to that of catecholamine release, involving calcium-dependent and energy-dependent steps.
We acknowledge the valuable technical assistance of Mr. John Gillespie and Mrs. Roselle Poisner.
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