Abstract
Summary
Vitamin A administered concurrently with triamcinolone acetonide prevented the effects of steroid on granuloma wet weight, vascularity, hydroxyproline, protein, and DNA. Although vitamin A blocked the general inhibitory effects of glucocorticoid treatment on granuloma growth, decreases of both prolyl hydroxylase activity and proteinaceous hydroxyproline formation were observed. These results indicate that vitamin A did not prevent the specific effects of glucocorticoids on prolyl hydroxylase activity and hydroxyproline formation.
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