Abstract
Summary
These data provide evidence that (i) the peak level and duration of the serum interferon response induced in mice by Bru-Pel is similar to that induced by some viruses and poly(I:C); (ii) the induction of interferon is markedly reduced after multiple injections of Bru-Pel; (iii) when administered as an interferon inducer, Bru-Pel does not appear to be as effective as poly(I:C) in protecting mice infected with either encephalomyocarditis virus or Herpesvirus hominis type 2; and (iv) when given 10-14 days prior to virus inoculation, Bru-Pel is effective as a nonspecific enhancer of host resistance to viral infection. These data suggest that Bru-Pel, in addition to its use as an interferon inducer, may have a role as a nonspecific potentiator of host resistance similar to that which has been reported for other bacterial agents such as C. parvum and BCG.
The authors would like to thank James T. Richards for excellent technical assistance.
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