Potassium Cyanate,An in Vitro Inhibitor of Lymphocyte Blast Transformation without in Vivo Activity 1

Abstract

Summary

Potassium cyanate (400 μg/ml) inhibited the blastogenesis of lymphocytes in response to PHA and the response of lymphocytes in mixed lymphocyte cultures. Cyanate administered to mice at a dose of 30 mg per kg per day did not delay allograft rejection.

The authors wish to thank Dr. Sandra Nehlsen for help with the skin grafting.