Difference in the Number of Insulin Binding Sites between Cortisol-Sensitive and Cortisol-Resistant Lymphoma P1798 Cells

Abstract

Summary

Cortisol-sensitive and cortisol-resistant lymphoma PI798 cells specifically bind [¹²⁵I]insulin. Resistant lymphocytes bind 40% less insulin than sensitive cells. These results suggest that insulin (or insulin-like substances) may play a role in growth regulation and/or response of this tumor to glucocorticoid therapy.