Abstract
Summary
The distribution of labeled mi-crospheres within the renal cortex was used to evaluate the influence of physiological amounts of antidiuretic hormone on intra-renal blood flow distribution in hypophysec-tomized dogs and in rats with hereditary diabetes insipidus. In both species, intravenous infusions of ADH caused a significant decrease in the ratio of inner to outer cortical blood flow. The change in blood flow distribution observed in the hypophysecto-mized dog with ADH was primarily a consequence of a decrease in inner cortical blood flow. No consistent changes in outer cortical blood flow were found. Also in the dog, glomerular filtration rates and electrolyte excretion rates (Na and K) increased following ADH. In contrast, ADH infusion into Brattleboro rats caused no change in glomerular filtration rate or excretion of Na and K.
I would like to thank Dr. Carl Hansen of NIH for kindly supplying our Brattleboro breeders. The excellent technical assistance of Mrs. Christine Eldon is gratefully acknowledged.
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