Abstract
Summary
Low level direct renal nerve stimulation increases renal tubular sodium reabsorption in the absence of changes in glomerular filtration rate, renal blood flow, or intrarenal distribution of blood flow. Blockade of this response with phenoxyben-zamine (or guanethidine) supports the interpretation that it is mediated by direct adre-nergic innervation of the renal tubule.
This work was supported by USPHS Grant Nos. HL 13765 and AM 15843, and Program Project No. HL 14388, and grants from the Iowa Heart Association. Mr. Zambraski was supported by a National Defense Education Act Fellowship. Drs. DiBona and Kaloyan-ides were Clinical Investigators, Veterans Administration. We are grateful to Smith, Kline and French Research Laboratories for a generous supply of phenoxy-benzamine.
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