Abstract
Summary
Renal artery constriction (RAC) to 30% of normal flow for 12 hr in the unilaterally nephrectomized dog produced a marked increase in both erythropoi-etin titers and prostaglandin E (PGE) levels in the blood. In dogs pretreated prior to RAC with indomethacin, a potent inhibitor of prostaglandin synthetase, there was no significant increase in either PGE or eryth-ropoietin levels as compared to zero-time control values. These data suggested an involvement of renal PGE in the generation of erythropoietin following RAC.
The authors gratefully acknowledge the excellent technical assistance of Mr. Jesse Brookins, Ms. Patricia Dargon, Mr. Rene Stiaes, and Mrs. Jacqueline Frailey.
Get full access to this article
View all access options for this article.