Abstract
Summary
Activity of lysyl oxidase, an enzyme responsible for production of alde-hydic precursors for lysine-derived collagen crosslinks, was measured in tibial meta-physes from chicks receiving different dietary levels of vitamin D and Ca for 2 weeks after hatching. Enzyme activities were increased twofold in D-deficient chicks compared to activities from chicks receiving control levels of vitamin D. Addition of Ca to the D-deficient diet had no effect on lysyl oxidase activity. It is suggested that vitamin D may play a role in the age-related decrease in lysyl oxidase activity that normally occurs in chick bone.
We thank Unni Kristoffersen, Catherine Lane, Rachel McNeil, and Lola Rigby for their technical assistance, and Jean Cochran for typing the manuscript. This investigation was supported by NIH Research Grant Number DE 02668 from the National Institute of Dental Research, and by NIH Grant Number RR 05333 from the Division of Research Facilities and Resources. One of us (W.G.) was supported by NIH Postdoctoral Fellowship Number DE 01658 during this study.
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