Abstract
Summary
Human peripheral monocytes demonstrated a higher IgG receptor activity in vitro after incubation with multistranded polynucleotides (poly(I:C) and poly(I:C:U)) after 6-hr cultivation periods. These changes were most pronounced using SRBC coated with low anti-Forssman antibody concentrations (EA, 1:1600 and 1:6400). Polyinosinic and polycytidylic acids failed to show changes in receptor activity. These findings suggest monocyte activation in vitro by multistranded polynucleotides and may in part explain their antitumor activity.
This research was supported in part by the National Insititutes of Health USPHS Grant No. AI-12478-02 and the National Leukemia Association, Inc., and in part by Deutsche Forschungsgemeinschaft.
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