Abstract
Summary
Weanling ICR albino Swiss mice were inoculated ip with 1.9 × 104 PFU of coxsackievirus B-3 (Nancy) and subsequently forced to swim vigorously daily in a preheated pool (33°). Viremias and virus in hearts of exercised mice were respectively 75 × 1000 × greater than in infected, but not exercised mice. At 24 hr after inoculation, pooled serum from mice that had been swum had no circulating interferon, while infected but not swum mice had interferon activity at a dilution of 1:10. At 72 hr after infection, circulating interferon disappeared from infected (not swum) mice, but continued to be present in high titers through the sixth day in sucklings forced to swim. Interferon was first detected in the hearts of both groups at 48 hr. Quantities in both infected groups were generally similar.
Neutralizing antibodies were found in these baby mice on the 13th day of infection and were 16 × greater in nurslings that were not exercised. Measures of corticosterone taken at 4 pm daily were similar in infected, infected-swum, and uninfected mice.
The work presented in this paper was aided by PHS Grant from the National Institute of Allergy and Infectious Diseases (No. AI 00261-11); a grant from the American Heart Assn. (No. 73-773); and a grant from Skillman Foundation for general support of research in infectious diseases.
We wish to thank Elizabeth Jane Bailey, Vera Tripp, Susie Harvey, and Babette Jackson for their assistance in these studies.
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