Abstract
Summary
The iv injection of 7-ketocholesterol into rabbits, made soluble by combining with bile salts, inhibited cholesterol uptake by the aorta. However, the inhibition was not as marked or as uniform as previously demonstrated in in vitro experiments. This difference may have been the result of lower plasma concentrations of 7-ketocholesterol in the injected animals. Gastric feeding of 7-ketocholesterol failed to inhibit aortic cholesterol uptake, probably because of inadequate plasma concentrations of the inhibitory steroid. The results suggest that the mechanism of 7-ketocholesterol on aortic cholesterol uptake is through competitive inhibition.
The authors wish to express their thanks to Mrs. Arpine Grenier and Mrs. Elana Colby for their technical assistance, and to Miss Barbara Biedebach and Mrs. Cindy Curry for their help in the preparation of this manuscript. We also appreciate the advice of Dr. George Popjak.
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