Abstract
Summary
The species-specific hypoglycemic activity of two 2-triphenylphosphor-anylideneacetophenones is described. 2-Triphenylphosphoranylideneacetophenone (SK&F 45359) and 2-triphenylphosphor-anylidene-m-trifluoromethyl-acetophenone (SK&F 62775) were hypoglycemic in various rat models, but failed to exhibit hypoglycemic activity in other species.
The authors appreciate the capable technical assistance of Mrs. L. Cieslinski, Mrs. Y. Li, and Mrs. J. Rush.
The interest expressed by Dr. H. Green, Director of Biochemistry, Smith Kline & French Laboratories, is also appreciated.
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