Angiotensin II Stimulation of 5'-Adenylic Acid Deaminase 1

Abstract

Summary

Angiotensin II has been found to stimulate 5'-adenylic acid deaminase from rabbit skeletal muscle. Stimulation was discernible around 10⁻⁹ M and peak stimulation of about threefold was seen at 10⁻⁷ M, concentrations approximating those required for stimulation of vascular smooth muscle or adrenal glomerulosa cells. Higher concentrations produced less stimulation. Adenosine triphosphate stimulated to the same degree, but a concentration of 10⁻⁵ M was required for maximum stimulation, while maximum stimulation with sodium or potassium required 0.5 M and 0.75 M, respectively. Although the physiologic significance of these observations has not been established, these data suggest an intracellular role for angiotensin II.