Abstract
Summary
Dialysis of a saline-infused against a noninfused dog was associated with a significant increase in Na excretion in both animals without a significant change in creatinine clearance or filtered Na. This indicates that there was movement by diffusion of a humoral agent between the two animals. The observed increase in Na excretion in the noninfused animal resulted from gain of a natriuretic hormone, since in a second series of experiments a natriuretic rather than antinatriuretic hormone appeared to be involved.
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