Abstract
Summary
Cordycepin (3-deoxyadenosine), an inhibitor of poly (a) synthesis, was found to inhibit the induction of the endogenous type “C” RNA virus by 5-iodo-2′-deoxyuridine in a line of Fischer rat embryo cells (H43) grown in vitro, and when continuously incorporated into the medium at those same concentrations, it was found to protect the cells from transformation by the chemical carcinogen 3-methylcholanthrene.
The authors are deeply grateful to Drs. Aaron E. Freeman, Mina Lee Vernon, and Janet Hartley for their advice in the preparation of this manuscript, and to Dr. Bernard Sass for the pathological diagnosis of the tumors.
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