The Matrix of Rat Calvarium as Transformant of Fibroblasts 1

Abstract

Summary

Allogeneic transplantation of coarse powders of the rat calvarial matrix to subcutaneous spaces resulted in transformation of fibroblasts to chondroblasts and osteoblasts. The emergence of new phenotypes was quantitated by determination of alkaline phosphatase activity and ⁴⁵Ca incorporation. A comparison of the matrices from rat calvarium and diaphyseal bone revealed that matrix of the shaft of long bones is more potent as transformant than matrix of the vault of the skull.