Abstract
Summary
19-Norspiroxenone, a potent anti-estrogen with no known estrogenic action, produces a striking arrest of spermatogenesis in the early stages of meiosis in the adult male rat with a complete block of fertility.
Aided by grants from the Whitehall Foundation and the Rockefeller Foundation and by a contract from NICHD, No. 1-HD-3-2746. A. S. Goldman is a recipient of Career Development Award No. HD-13,628 from U.S.P.H.S. We acknowledge the excellent technical assistance of Mary K. Baker and also wish to thank Dr. Glen Arth of Merck and Company, Rahway, NJ, for generously supplying the 19-norspiroxenone.
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