Adenosine,AMP,Cyclic AMP,Theophylline and the Action and Production of Erythropoietin

Abstract

Summary

Erythropoiesis, as measured by the uptake of ⁵⁹Fe into plethoric mice, is stimulated by adenosine, AMP, cyclic AMP, and dibutyryl cyclic AMP, but not by cytidine, its nucleotides or cyclic GMP. This stimulation is erythropoietin dependent, because it is prevented by anti-erythropoietin. Theophylline neither stimulates erythropoiesis nor potentiates the action of erythropoietin on bone marrow cells in plethoric mice. Theophylline does potentiate the production of erythropoietin in rats following a brief hypoxic exposure but does not cause a similar increase in mice.

This work was supported by the United States Atomic Energy Commission.